TB-500 (Thymosin Beta-4)

Thymosin Beta-4

Level C
TB-500 (Thymosin Beta-4)

Editor: Dr. Jobby John, PharmD, FACA

Peptide Ledger review boards: Medical Review Board (Dr. Jobby John, PharmD, FACA; Dr. Richard Harris, MD, PharmD, MBA; Dr. Tracy Neal, MD; Dr. John Thoppil, MD; Dr. Natalie Kash, MD; Dr. Rahil Roopani, MD)Pharmacist Review Committee (Rachel Kuretich, PharmD, PharmD; Daniel Alonso, PharmD, PharmD; Christina Gunter, PharmD, PharmD; Patrick Gurley, PharmD, MS, PharmD, MS; Gyu-Hee Min, PharmD, PharmD)

Reviewed November 13, 2025

References are being re-verified against PubMed and will return with review dates.

C
Emerging Evidence
Preclinical and animal studies with limited human data

Preclinical and animal studies with limited human data

TB-500 (Thymosin Beta-4) is a naturally occurring peptide present in high concentrations in blood platelets, wound fluid, and tissues. It plays a crucial role in tissue repair, wound healing, and reducing inflammation. TB-500 is administered by subcutaneous or intramuscular injection and is being studied for muscle recovery, tendon/ligament repair, and post-surgical healing.

Thymosin Beta-4 is being studied for effects on cell migration, stem cell differentiation, and tissue remodeling, including actin polymerization. TB-500 is also being studied for:

  • Inflammation, via cytokine release
  • Angiogenesis (new blood vessel formation)
  • Adhesion and fibrosis
  • Neural regeneration
  • Wound healing and tissue repair

Generally well-tolerated with minimal side effects:

  • Mild injection site reactions (redness, swelling)
  • Transient headache or fatigue
  • Rare: dizziness, flushing

Serious adverse events are rare but should be reported immediately.

Contraindicated in:

  • Active malignancy (theoretical concern due to angiogenesis promotion)
  • Pregnancy and lactation (insufficient safety data)
  • Hypersensitivity to TB-500 or excipients

Precautions:

  • Use only under medical supervision
  • Monitor injection sites for reactions
  • Limited long-term human safety data

⚠️ Important safety information above

Dosing considerations for clinicians

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Coming to the Lake Hills Pharmacy pipeline.

Lake Hills Pharmacy is preparing peptide formulations in anticipation of regulatory guidance on compounded peptides. Planned strengths and dosing are shared with verified clinicians.

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For Healthcare Providers

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For Patients

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Important Information About Compounded Medications

These peptides are not FDA-approved but are commonly used by providers and patients under medical supervision. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. We provide evidence-based information from current research to help navigate this evolving field. Our goal is clear, evidence-based information for clinicians, with professional oversight at every step.

Lake Hills Pharmacy | Licensed 503A Compounding Pharmacy | Professional Medical Oversight Required