Ipamorelin

Growth Hormone Secretagogue

Level C
Ipamorelin

Editor: Dr. Jobby John, PharmD, FACA

Peptide Ledger review boards: Medical Review Board (Dr. Jobby John, PharmD, FACA; Dr. Richard Harris, MD, PharmD, MBA; Dr. Tracy Neal, MD; Dr. John Thoppil, MD; Dr. Natalie Kash, MD; Dr. Rahil Roopani, MD)Pharmacist Review Committee (Rachel Kuretich, PharmD, PharmD; Daniel Alonso, PharmD, PharmD; Christina Gunter, PharmD, PharmD; Patrick Gurley, PharmD, MS, PharmD, MS; Gyu-Hee Min, PharmD, PharmD)

Reviewed November 13, 2025

References are being re-verified against PubMed and will return with review dates.

C
Emerging Evidence
Preclinical and animal studies with limited human data

Preclinical and animal studies with limited human data

Ipamorelin is a selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin levels. It is being studied for anti-aging, body composition, and metabolic health.

Ipamorelin acts as a ghrelin receptor agonist, selectively binding to GH secretagogue receptors in the pituitary gland. Unlike other GH peptides, it:

  • Stimulates GH release without elevating cortisol (stress hormone)
  • Doesn't significantly affect prolactin levels
  • Provides pulsatile GH secretion (mimics natural patterns)
  • Researchers are studying its role in IGF-1 production
  • Researchers are studying its role in fat loss and muscle preservation
  • Researchers are studying its role in bone density
  • Researchers are studying its role in recovery and sleep quality

Excellent safety profile with minimal side effects:

  • Mild injection site reactions
  • Transient headache
  • Increased appetite
  • Water retention (mild, rare)
  • Flushing (rare)

Unlike GHRP-6 or GHRP-2, Ipamorelin does NOT significantly increase cortisol or appetite.

Contraindicated in:

  • Active malignancy
  • Pregnancy and lactation
  • Hypersensitivity to Ipamorelin or excipients

Precautions:

  • Monitor IGF-1 levels
  • Use caution in diabetes
  • Assess pituitary function
  • Requires medical supervision

āš ļø Important safety information above

Dosing considerations for clinicians

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Coming to the Lake Hills Pharmacy pipeline.

Lake Hills Pharmacy is preparing peptide formulations in anticipation of regulatory guidance on compounded peptides. Planned strengths and dosing are shared with verified clinicians.

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For Healthcare Providers

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For Patients

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Important Information About Compounded Medications

These peptides are not FDA-approved but are commonly used by providers and patients under medical supervision. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. We provide evidence-based information from current research to help navigate this evolving field. Our goal is clear, evidence-based information for clinicians, with professional oversight at every step.

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